Bioactivity of Mupirocin Nanoparticle-Loaded Hydrogel against Methicillin-Resistant Staphylococcus aureus (MRSA)

This novel study investigated the loading of mupirocin nanoparticles into a hydrogel which was expected to enhance antibacterial activity mupirocin. The inhibition isoleucyl-tRNA synthetase and global gene expression in methicillin-resistant Staphylococcus aureus (MRSA) by nanoparticle-loaded (MLH) pure compared. MLH rapidly inhibited growth bacterial populations after 1 h treatment. At 12 h, MRSA. Transcriptome profiles MRSA showed that alterations treatment with were similar those at MICs. These included changes DNA transcription, translation, replication pathways, fold these genes decreased more than only released from systems then drug permeated cell wall bound synthetase. research also could be further developed for use clinics infected wounds.